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Neither should be used with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping one, as doing so can increase the risk of dangerously high blood pressure and serotonin syndrome
Furthermore, GLP-1 RAs exhibit neuroprotective properties observed in models of neurodegenerative diseases, including Alzheimers and Parkinsons, which may extend to the treatment of psychiatric conditions [26,79]
While it activates the GLP-1 receptor, Zepbound also targets the GIP (glucose-dependent insulinotropic polypeptide) receptor, making it a dual receptor agonist
Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans
Additionally, laboratory evaluations by Eli Lilly discovered bacterial contamination and chemical impurities in various unverified products marketed as tirzepatide